ADH has two actions, one on the kidney and the other on vascular smooth muscle, these actions are mediated by different receptors, different intracellular mechanisms, and different secondary messengers.

a. The major action of ADH is to increase the water permeability of principal cells in the late distal tubule and collecting duct.

b. The receptor for ADH on the principal cells is a V2 receptor, which is coupled to adenylyl cyclase via a Gs protein. 

c. The second messenger is cAMP, via phosphorylation steps, directs the insertion of water channels, aquaporin 2 (AQP2), in luminal membranes.

d. The receptor for ADH on the principal cells is a V1 receptor, which is coupled to phospholipase C via Gq protein.

Which one of the following combination of above statements is correct?

TLS Online TPP Program

#Question id: 24491

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence CCUUAACU

TLS Online TPP Program

#Question id: 24490

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence UACUAAC?

TLS Online TPP Program

#Question id: 24489

#Unit 3. Fundamental Processes

Two transesterification reactions takes place for 2 exon -1 intron configuration. Choose the correct  statement 

a. First transesterification is always caused by exon 1 -3’OH

b. second transesterification is catalysed variably either by external G or branch point while .

c. First transesterification is catalysed variably either by external G or branch point while 

d. second transesterification is always caused by exon 1 -3’OH.

TLS Online TPP Program

#Question id: 24464

#Unit 3. Fundamental Processes

rRNA are encoded by two type of RNA pol. RNA pol I and RNA pol III in which 5.8s rRNA is encodes by …………. While 5s rRNA encoded by ……

TLS Online TPP Program

#Question id: 4350

#Unit 3. Fundamental Processes

Portions of the DNA sequences of normal and mutant b-globin genes are shown. The most plausible explanation for why the indicated mutation (changing an A to a G) results in the disease b-thalassemia is that the mutation

TLS Online TPP Program

#Question id: 4349

#Unit 3. Fundamental Processes

RNA Pol IV and Pol V