Which of the following is INCORRECT about insulinoma? -triyambak.org

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#Question id: 20289

Which of the following is INCORRECT about insulinoma?

#Unit 7. System Physiology – Animal

It is much rarer than diabetes excessive insulin production occasionally occurs from an adenoma of an islet of Langerhans.
About 10 to 15 percent of these adenomas are malignant, and occasionally metastases from the islets of Langerhans spread throughout the body.
Indeed, more than 1000 grams of glucose have had to be administered every 24 hours to prevent hypoglycemia in some of these patients.
The pancreatic beta cells become “exhausted” or damaged and are unable to produce enough insulin to prevent more severe hyperglycemia.

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#Question id: 15306

#Unit 4. Cell Communication and Cell Signaling

The transformation of a normal cell to a cancer cell is accompanied by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β ‐catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E‐Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras