An individual is having an inversion in heterozygous condition. The regions on normal chromosome are marked as A, B, C, D, E, F, G while the chromosome having inversion has the regions as a, b, e, d, c, f, g. The diagram given below shows pairing of these two homologous chromosomes during meiosis and the site of a crossing over is indicated:

The following statements are given to describe the inversion and the consequence of crossing over shown in the above diagram:

A. This is a paracentric inversion

B. This will generate a dicentric and an acentric chromosome following separation of chromosomes after crossing over

C. This will generate two recombinant chromosomes with deletion and other parental chrmosome following separation of chromosomes after crossing over

D. 50 % gametes will be non viable due to deletion or duplication of chromatids

E. The gametes having recombinant chromatid or parental inversion chromatids will be non-viable

#Question id: 1051

#Unit 4. Cell Communication and Cell Signaling

The shape of the virus is determined by its

#Question id: 16316

#Unit 7. System Physiology – Animal

#Question id: 1518

#Unit 4. Cell Communication and Cell Signaling

Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.

A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.

B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.

C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.

D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.

Which of the following statements are incorrect?

#Question id: 12969

#Unit 10. Ecological Principles

#Question id: 26499

#Unit 3. Fundamental Processes