#Question id: 1519
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to the FOXO3a protein.
A. In the presence of growth factors, FOXO3a is non phosphorylated and mainly localizes to the nucleus, where it activates transcription of several genes encoding pro-apoptotic proteins.
B. When growth factors are removed from the cells, PKB becomes active and phosphorylates FOXO3a.
C. Phosphorylated FOXO3a binds to cytosolic phosphoserine-binding protein 14-3-3 to bind FOXO3a and thus sequester it in the cytosol.
D. Dephosphorylated FOXO3a binds to cytosolic phosphoserine-binding protein 14-3-3 to bind FOXO3a and thus sequester it in the cytosol.
Which of the following is correct?
#Question id: 1518
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.
A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.
B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.
C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.
D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.
Which of the following statements are incorrect?
#Question id: 1263
#Unit 4. Cell Communication and Cell Signaling
The major classes of CAMs include
a. cadherins. b. fibronectin. c. Ig-superfamily CAMs. d. P-selectins.
#Question id: 1264
#Unit 4. Cell Communication and Cell Signaling
Desmosomes
#Question id: 1265
#Unit 4. Cell Communication and Cell Signaling
An example of an integrin containing cell junction is
#Question id: 1266
#Unit 4. Cell Communication and Cell Signaling
Integrins