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TLS Online TPP Program

#Question id: 12958

The Norway rat (Rattus Norvegicus), a widespread pest, was controlled for about a decade by the anticoagulant warfarin. This chemical substance, placed in food pellets, is absorbed by the intestinal tract and inhibits the clotting of blood. After a population decline for about 10 years, rat populations increased and stabilized. In one European population, as illustrated in the graph below, the percentage of rats resistant to warfarin has remained fairly stable over a number of years

Resistance to warfarin is governed by a dominant autosomal gene, R. More than 15 percent of the resistant animals are heterozygous at this locus (Rr). The table below indicates the response to warfarin and relative reproductive fitness of individuals that are homozygous or heterozygous for the dominant gene (R). The RR individuals have a 20-fold increase in vitamin K requirement over individuals.


Fitness is a measure of the reproductive success of a particular genotype. The highest fitness is 1.00.

The strong dependence of RR individuals on large quantities of vitamin K probably is responsible for

#Unit 10. Ecological Principles
  1. Their lowered fitness
  2. Their susceptibility to warfarin
  3. Their superiority to heterozygotes (Rr)
  4. Their increasing numbers in the population each generation
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TLS Online TPP Program

#Question id: 26464

#Unit 3. Fundamental Processes

Choose the correct statement During abortive Transcription 
a. Abortive synthesis takes before escaping the promoter (-10 to +2), entering the elongation phase 
b. Abortive synthesis produces and releases short RNA transcripts of 10 nucleotides 
c. The major phenomenon which is responsible is Brownian ratchet 
d. Three general models were associated is “Scrunching”
TLS Online TPP Program

#Question id: 16493

#Unit 3. Fundamental Processes

35S promoter sequences derived from cauliflower mosaic virus shows which type of expression.
TLS Online TPP Program

#Question id: 24498

#Unit 3. Fundamental Processes

SR proteins are involved in exon definition in which they interact with U1 and U2AF forming the commitment for
TLS Online TPP Program

#Question id: 24491

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence CCUUAACU
TLS Online TPP Program

#Question id: 24490

#Unit 3. Fundamental Processes

There are three type of Splicing signals 1. Major U2-type or GU-AG introns 2. Minor U12-type or AU-AC introns & 3. Minor U12-type with GU-AG introns (hybrid type), which of the following is responsible for the recognition of branch point sequence UACUAAC?
TLS Online TPP Program

#Question id: 24489

#Unit 3. Fundamental Processes

Two transesterification reactions takes place for 2 exon -1 intron configuration. Choose the correct  statement 
a. First transesterification is always caused by exon 1 -3’OH
b. second transesterification is catalysed variably either by external G or branch point while .
c. First transesterification is catalysed variably either by external G or branch point while 
d. second transesterification is always caused by exon 1 -3’OH.