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TLS Online TPP Program

#Question id: 3426

Fitness of three different genotypes is given in population I and II, under natural selection which of the following statement are correct?

#Unit 11. Evolution and Behavior

  1. In population I selection against recessive allele A2 while population II selection against dominant allele A2

  2. In population I selection against dominant allele A1 while population II selection against recessive allele A1

  3. In population I selection against recessive allele A1 while population II selection against dominant allele A1

  4. In population I A1 allele increases while Population II A2 allele increases

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TLS Online TPP Program

#Question id: 909

#Unit 1. Molecules and their Interaction Relevant to Biology

Most proteins denature at both high and low pH. At high pH, the ionization of internal tyrosines is thought to be the main destabilizing influence, whereas at low pH, the protonation of buried histidines. A titration curve for the unfolding of the enzyme ribonuclease is shown in Figure. Given the relation between the titration curves for protein unfolding and histidine protonation, which of the following conclusion can be drawn correctly?

A. The sharp transition in graph indicates a highly cooperative process; when the protein starts to unfold, it completes the process rapidly

B. The sharp transition in graph indicates a highly noncooperative process

C. Several buried histidines can ionize when the chain starts to unfold, so that when one goes, they all go together due to cooperative behaviour of protein folding

D. Buried histidine (pK of 4 in this example) becomes accessible to solvent, its pK will shift toward its normal value of 6, significantly steepening its titration curve.
TLS Online TPP Program

#Question id: 908

#Unit 1. Molecules and their Interaction Relevant to Biology

Molecular chaperones are a class of proteins that play a role
TLS Online TPP Program

#Question id: 907

#Unit 1. Molecules and their Interaction Relevant to Biology

Thermodynamics of protein folding is depicted as a free energy vs folding process:

Choose the correct match for regions mentioned in the figure

A.

1. Molten globule

B.

2. Unfolded

C.

3. Transition state

D.

4. Folded

TLS Online TPP Program

#Question id: 906

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is least likely to result in protein denaturation?
TLS Online TPP Program

#Question id: 905

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct about chaperones

A) renature and denatured proteins.

B) help cells repair damage due to heat shock.

C) assist protein self assembly.

D) donot use ATP to fold proteins.
TLS Online TPP Program

#Question id: 904

#Unit 1. Molecules and their Interaction Relevant to Biology

In addition to self assembly, some proteins fold with the help of