Following statements are regarding to the spindle position checkpoint pathway in budding yeast.

A. During interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. Inactive Tem1-GDP associates with the spindle pole body (SPB) nearest to the bud as soon as the mitotic spindle forms.

B. If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.

C. Tem1-GDP activates a protein kinase cascade, which then promotes the release of active Cdc14 from the nucleolus and exit from mitosis.

D. If the spindle apparatus fails to place the daughter SPB in the bud, Kin4 (cyan), an inhibitor of Tem1, is recruited from the parent cell cortex to the parent-cell-located SPB and maintains Tem1 in the GTP-bound form, and mitotic exit does not occur.

Which of the following are correct?

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Following statements are regarding to control of the G1–S phase transition in budding yeast.

A. G1 cyclin-CDK complexes stimulate the formation of G1/S phase cyclin-CDKs, which then initiate bud formation, centrosome duplication, and DNA replication. In yeast, the G1 cyclin gene is called CLN3.

B. Once sufficient Cln3 is synthesized from its mRNA, Cln3-CDK complexes phosphorylate and activate the transcriptional repressor Whi5.

C. Phosphorylation of Whi5 promotes its export out of the nucleus, allowing the transcription factor complex SBF to induce transcription of the G1/S phase cyclin genes CLN1 and CLN2 as well as other genes important for DNA replication.

D. Once produced, Cln1/2-CDKs contribute to further Whi5 phosphorylation. This positive feedback loop ensures the rapid accumulation of G1/S phase cyclin-CDKs.

Which of the following statements are correct?

#Question id: 19753

#SCPH05 I Biotechnology