During ubiquitin-mediated protein degradation in various events of cell cycle, ubiquitin-protein ligases ubiquitinylate substrate proteins, marking them for degradation by proteasomes. Cyclins are degraded through the action of two different ubiquitin-protein ligases, SCF and the anaphase-promoting complex or cyclosome. Following statements are regarding to SCF and APC/C.

A. SCF controls the G1–S phase transition by degrading G1/S phase cyclins and, CDK inhibitory proteins.

B. APC/C degrades S phase and mitotic cyclins, thereby promoting the exit from mitosis.

C. SCF and APC/C are multi-subunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin protein ligases.

D. SCF and APC/C belong to the different ubiquitin-protein ligase family, their regulation is same.

E. SCF recognizes its substrates only when they are phosphorylated.

F. SCF and APC/C both recognizes its substrates only when they are phosphorylated.

Which of the following is incorrect?

#Question id: 11083

#I Life Science/ Life Sciences Group – I-V

A 55-year-old male has a pulmonary embolism that partially blocks the blood flow to his right lung. Which point on the ventilation-perfusion line of the O2-CO2 diagram corresponds to the alveolar gas of his right lung?

#Question id: 11083

#SCPH28 | Zoology

A 55-year-old male has a pulmonary embolism that partially blocks the blood flow to his right lung. Which point on the ventilation-perfusion line of the O2-CO2 diagram corresponds to the alveolar gas of his right lung?

#Question id: 11084

#I Life Science/ Life Sciences Group – I-V

The next diagram shows two lung units (S and T) with their blood supplies. Lung unit S has an ideal relationship between blood flow and ventilation. Lung unit T has a comprised blood flow. What is the relationship between alveolar dead space (DALV), physiologic dead space (DPHY) and anatomic dead space (DANAT) for these lung units?

#Question id: 11084

#SCPH28 | Zoology

The next diagram shows two lung units (S and T) with their blood supplies. Lung unit S has an ideal relationship between blood flow and ventilation. Lung unit T has a comprised blood flow. What is the relationship between alveolar dead space (DALV), physiologic dead space (DPHY) and anatomic dead space (DANAT) for these lung units?

#Question id: 11085

#I Life Science/ Life Sciences Group – I-V

The diagrams show changes in the partial pressures of oxygen and carbon dioxide as blood flows from the arterial end to the venous of the pulmonary capillaries. Which diagram best depicts the normal relationship between Po2 (red line) and Pco2 (green line) during resting conditions?

#Question id: 11085

#SCPH28 | Zoology

The diagrams show changes in the partial pressures of oxygen and carbon dioxide as blood flows from the arterial end to the venous of the pulmonary capillaries. Which diagram best depicts the normal relationship between Po2 (red line) and Pco2 (green line) during resting conditions?