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TLS Online TPP Program

#Question id: 12186

In 2001, the Nobel Prize in Physiology or Medicine was awarded to three cell cycle scientists. Paul Nurse was recognized for his studies with the fission yeast S. pombe, in particular for the discovery and characterization of the wee1+ gene. What did the characterization of the wee1+ gene tell us about cell cycle control?

#SCPH06 I Botany
  1. The dual-specificity protein kinase Wee1 phosphorylates CDKs on the activatory tyrosine 15.
  2. Yeast cells with a defective wee1+ gene activate S phase CDKs prematurely and hence experience premature entry into DNA replication. 
  3. Fission yeast cells carrying a CDK1 mutation in which the tyrosine 15 residue is replaced by phenylalanine (which is structurally similar to tyrosine but cannot be phosphorylated) show the premature mitotic CDK activation and entry into mitosis.
  4. The dual-specificity protein phosphatase Wee1 dephosphorylates CDKs on the inhibitory tyrosine 15.

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#Question id: 4600

#SCPH28 | Zoology

Scientific theories ________.
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#Question id: 5553

#SCPH28 | Zoology

The notochord is a ___ structure in vertebrate embryos that lies under the ___, and is bordered by ___.
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#Question id: 8893

#SCPH06 I Botany

While sampling marine plankton in a lab, a student encounters large numbers of fertilized eggs. The student rears some of the eggs in the laboratory for further study and finds that the blastopore becomes the mouth. The embryo develops into a trochophore larva and eventually has a true coelom. These eggs probably belonged to a(n)
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#Question id: 1080

#SCPH01 Biochemistry

 In the formation of biofilms, such as those forming on unbrushed teeth, cell signaling serves which function?
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#Question id: 414

#SCPH05 I Biotechnology

The hydrolysis of phosphoenolpyruvate proceeds with a DG'° of about –62 kJ/mol. The greatest contributing factors to this reaction are the destabilization of the reactants by electostatic repulsion and stabilization of the product pyruvate by: