Calcineurin phosphatase, dephosphorylates and activates the transcription factor, Nuclear Factor Associated with T cells (NFAT).

TLS Online TPP Program

#Id: 10469

#Unit 4. Cell Communication and Cell Signaling

Three mechanisms for LOH of tumor-suppressor genes:

Inactivating mutation or deletion

Chromosome missegregation

Mitotic recombination

TLS Online TPP Program

#Id: 2996

#Unit 3. Fundamental Processes

The coupled 5'-3' synthetic/ 3'-5' exonucleolytic action is used most extensively for filling in short single-stranded regions in double-stranded DNA. These regions arise during lagging strand DNA replication.

TLS Online TPP Program

#Id: 5891

#Unit 3. Fundamental Processes

DNA binds in a large cleft composed of three domains. The “palm” domain has important conserved sequence motifs that provide the catalytic active site. The “fingers” are involved in positioning the template correctly at the active site. The “thumb” binds the DNA as it exits the enzyme, and is important in processivity.

TLS Online TPP Program

#Id: 1665

#Unit 4. Cell Communication and Cell Signaling

Clinical trials

Phase I clinical trials assess human safety; a small number of volunteers are monitored closely for adverse side effects.

TLS Online TPP Program

#Id: 4012

#Unit 7. System Physiology – Animal

The inherent leakiness of the sinus nodal fibers to sodium and calcium ions causes their self-excitation.