Activated IRAK1/2, binds TRAF6, an E3 ubiquitin ligase, to the signalsome, and promotes the formation of an extended 2-D lattice formed by TRAF6-TRAF6 interactions.

TLS Online TPP Program

#Id: 1200

#Unit 7. System Physiology – Animal

In the granulosa cells,

All the androgens and much of the progesterone are converted into estrogens by the enzyme aromatase

TLS Online TPP Program

#Id: 1201

#Unit 7. System Physiology – Animal

Theca cells synthesize and secrete progesterone.

TLS Online TPP Program

#Id: 1202

#Unit 7. System Physiology – Animal

Three estrogens are present in the plasma of the human female:

1. β-estradiol

2. Estrone

3. Estriol

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#Id: 1203

#Unit 7. System Physiology – Animal

The principal estrogen secreted by the ovaries is β-estradiol.

TLS Online TPP Program

#Id: 1204

#Unit 7. System Physiology – Animal

Estrogens inhibit osteoclastic activity in the bones and therefore stimulate bone growth.

TLS Online TPP Program

#Id: 1205

#Unit 7. System Physiology – Animal

During female reproductive cycle, Estrogen stimulate rapid proliferation of the stromal cells and the epithelial cells of endometrium, before ovulation.