Inflammasomes

Multiprotein complex that promotes inflammation by processing inactive precursor forms of pro-inflammatory cytokines such as IL-1 and IL-18.

Proinflammatory cytokines IL-1β, TNF, and IL-6. 

TLS Online TPP Program

#Id: 2001

#Unit 3. Fundamental Processes

Histone biogenesis is primarily controlled by the regulation of histone mRNA abundance during the cell cycle. At this G1/S transition, the abundance of histone mRNAs is increased more than 30-fold due to elevated transcription; this process is regulated by the Cyclin E/Cdk2 complex.

TLS Online TPP Program

#Id: 2529

#Unit 13. Methods in Biology

The duration of primer extension is usually 2 min at 72°C

TLS Online TPP Program

#Id: 3170

#Unit 3. Fundamental Processes

The ter site is recognized by a unidirectional contrahelicase (called Tus in E. coli and RTP in B. subtilis) that recognizes the consensus sequence and prevents the replication fork from proceeding.

TLS Online TPP Program

#Id: 3160

#Unit 3. Fundamental Processes

Replication enzymes have large structures, with separate subunits for different activities. Repair enzymes have much simpler structures.

TLS Online TPP Program

#Id: 759

#Unit 3. Fundamental Processes

Four Steps for bacterial transcription

1. Promoter search->closed promoter complex -> open promoter complex

2. Abortive transcription->Promoter Escape->Initiation from +1 TSS 

3. Elongation

4. Termination