Poly-K63 ubiquitin chain brings TAK1 kinase and β subunit of I-κB

kinase, into close proximity so that TAK1 can phosphorylate and activate I-κB kinase

TLS Online TPP Program

#Id: 2389

#Unit 3. Fundamental Processes

In general, SR proteins bind to exonic splicing enhancers and the hnRNP proteins bind to exonic silencers

TLS Online TPP Program

#Id: 2390

#Unit 3. Fundamental Processes

Binding of SR proteins to ESEs promotes or stabilizes U1 binding to the 5’ splice site and U2AF binding to the 3’ splice site.

TLS Online TPP Program

#Id: 2391

#Unit 3. Fundamental Processes

The Nova and Fox families of RNA-binding proteins can promote or suppress splice site selection in a context-dependent fashion.

TLS Online TPP Program

#Id: 2392

#Unit 3. Fundamental Processes

Trans-splicing is rare in multicellular eukaryotes, it occurs as the primary mechanism to process precursor RNA into mature, translatable mRNAs in some organisms, such as trypanosomes and nematodes.

TLS Online TPP Program

#Id: 2393

#Unit 3. Fundamental Processes

The SL RNA provides an exon that is connected to the first exon of an mRNA by trans-splicing. The reaction involves the same interactions as nuclear cis splicing but generates a Y-shaped RNA instead of a lariat.

TLS Online TPP Program

#Id: 2394

#Unit 3. Fundamental Processes

In C. elegans, about 70% of genes are processed by the trans-splicing mechanism