Outside-in signaling

Binding of integrins to their ligands induces conformational changes in their cytoplasmic domains, directly or indirectly altering their interactions with cytoplasmic proteins

TLS Online TPP Program

#Id: 7199

#Unit 5. Developmental Biology

TLS Online TPP Program

#Id: 576

#Unit 2. Cellular Organization

The DNA-binding domain occupies residues 1–59. It contains two a-helices separated by a turn. This is a common DNA-binding motif known as the HTH (helix-turn-helix); the two a-helices fit into the major groove of DNA

TLS Online TPP Program

#Id: 10001

#Unit 4. Cell Communication and Cell Signaling

Vertebrates have three homologues of the Drosophila hedgehog gene: sonic hedgehog (shh), desert hedgehog

(dhh), and indian hedgehog (ihh)

TLS Online TPP Program

#Id: 10423

#Unit 4. Cell Communication and Cell Signaling

Tumor cells secrete a protein plasminogen activator that converts the serum protein plasminogen to the active protease plasmin.

TLS Online TPP Program

#Id: 441

#Unit 2. Cellular Organization

When spaced at about, consecutive AT base pair has 10 bp intervals as consecutive GC base pairs they are offset by 5 bp from runs of AT base pairs.