In mammals, the bipotential gonad appears to be moved into the female pathway (ovary development) by the Foxl2, Wnt4, and Rspo1 genes.

TLS Online TPP Program

#Id: 1498

#Unit 4. Cell Communication and Cell Signaling

P53 turned on  p2I/WAF-I, which binds to and inhibits the CDK/cyclin complexes for GI arrest

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#Unit 4. Cell Communication and Cell Signaling

P53 turned on sets of large intergenic noncoding RNAs to mediate transcription repression; and miRNAs.

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#Id: 1500

#Unit 4. Cell Communication and Cell Signaling

p2I -IincRNA, mediates the repressive properties of p53 by binding to specific chromatin complexes.

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#Id: 1501

#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 lose its suppressor function and acquire oncogenic function.

 

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#Unit 4. Cell Communication and Cell Signaling

p53 amyloid aggregates,

No transport from cytoplasm to the nucleus

Escape proteasome degradation

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#Unit 4. Cell Communication and Cell Signaling

The amyloid aggregation of p53 demonstrated by biophysical techniques:

X-ray diffraction 

Fourier transform infrared spectroscopy (FTIR)