TIR1 recruits AUX/ IAA proteins to the SCF -TIR1 complex in an auxin-dependent manner. Once recruited by auxin, AUX/IAA proteins are ubiquitinated by the E3 ligase activity of the SCF-TIR1 complex, which marks the protein for destruction by the 26S proteasome.

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#Id: 8168

#Unit 2. Cellular Organization

Rab GTPases 

associate with transport vesicles and act as key regulators of vesicle trafficking to and fusion with the appropriate target membrane.

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#Unit 2. Cellular Organization

Rab·GTP is enabled to bind to a variety of different proteins, known as Rab effectors.

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#Unit 2. Cellular Organization

In yeast Rab protein is the Sec4 and its effectors are exocyst and Type V Myosin.

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#Id: 8171

#Unit 2. Cellular Organization

In mammalian cells, Rab5 protein (early endosomes) and its effector protein known as EEA1 (early endosome antigen 1)

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#Unit 2. Cellular Organization

Effector proteins of Rab6 is Kinesin

Effector proteins of Rab27 is Type V Myosin

TLS Online TPP Program

#Id: 8173

#Unit 2. Cellular Organization