Nurturing Life Sciences
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#Unit 1. Molecules and their Interaction Relevant to Biology
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Fructose 2,6-bisphosphate binds to its allosteric site on PFK-1, it increases the enzyme’s affinity for its substrate fructose 6-phosphate and reduces its affinity for the allosteric inhibitors ATP and citrate
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Glucagon lowers the cellular level of fructose 2,6 bisphosphate, inhibiting glycolysis and stimulating gluconeogenesis.
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Accumulation of alanine, which can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis
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