Acute myeloid leukemias

characterized by DNA hypomethylation, due to inactivating mutations in an enzyme that catalyzes the methylation of CpG dinucleotides.

TLS Online TPP Program

#Id: 1147

#Unit 7. System Physiology – Animal

The endothelium of the glomerular capillaries is completely surrounded by the glomerular basement membrane along with specialized cells called podocytes.

TLS Online TPP Program

#Id: 1148

#Unit 7. System Physiology – Animal

Podocytes have numerous pseudopodia that interdigitate to form filtration slits along the capillary wall.

TLS Online TPP Program

#Id: 1149

#Unit 7. System Physiology – Animal

Stellate cells (mesangial cells )

Located between the basal lamina and the endothelium

They are similar to pericytes

TLS Online TPP Program

#Id: 1150

#Unit 7. System Physiology – Animal

Mesangial cells are contractile and play a role in the regulation of glomerular filtration. 

TLS Online TPP Program

#Id: 1151

#Unit 7. System Physiology – Animal

Glomerular filtration barrier is selective in determining which molecules will filter, based on their,

1. Size 

2. Electrical charge

TLS Online TPP Program

#Id: 1152

#Unit 7. System Physiology – Animal

Endothelium & epithelial cells, effectively prevents filtration of plasma proteins, because of strong negative electrical charges (associated with the proteoglycans).