In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC

TLS Online TPP Program

#Id: 6490

#Unit 3. Fundamental Processes

Strikingly, a number of TAFs resemble histones: nine of 14 TAPs contain a histone fold domain, though in most cases the TAFs lack the residues of this domain that are responsible for DNA binding. 

TLS Online TPP Program

#Id: 6491

#Unit 3. Fundamental Processes

Four TAFs do have some intrinsic DNA binding ability: TAF4b, TAF12, TAF9, and TAF6 are (distant) homologs of histones H2A, H2B, H3, and H4, respectively.  TAF4b/TAF12 and TAF9/TAF6 form heterodimers using the histone fold motif

TLS Online TPP Program

#Id: 6492

#Unit 3. Fundamental Processes

Binding of the TFIID complex in the initiation reaction regularly protects the region from -45 to -10.

TLS Online TPP Program

#Id: 6493

#Unit 3. Fundamental Processes

TLS Online TPP Program

#Id: 6494

#Unit 3. Fundamental Processes

Model of Formation of the DABPolF Complex

TLS Online TPP Program

#Id: 6495

#Unit 3. Fundamental Processes

TFIIB, TFIIE, and TFIIH are required to melt DNA to allow polymerase movement. The last factors to join the initiation complex are TFIIE and TFIIH.