MYC gene encodes a basic helix-loop-helix protein

include MAD, MAX, and MNT

TLS Online TPP Program

#Id: 10425

#Unit 4. Cell Communication and Cell Signaling

Let-7 miRNAs repress the translation of Ras mRNA and also targets MYC

TLS Online TPP Program

#Id: 10426

#Unit 4. Cell Communication and Cell Signaling

miR-15-a and miR-16-1, control the proliferation of 

B cells

TLS Online TPP Program

#Id: 10427

#Unit 4. Cell Communication and Cell Signaling

miR-21 targets PTEN phosphatase

TLS Online TPP Program

#Id: 10428

#Unit 4. Cell Communication and Cell Signaling

DNA methylation occurs at cytosines of CpG islands, leads to repression of the promoters. DNA hypermethylation & DNA hypomethylation is also a hallmark of cancer.

TLS Online TPP Program

#Id: 10429

#Unit 4. Cell Communication and Cell Signaling

Acute myeloid leukemias

characterized by DNA hypomethylation, due to inactivating mutations in an enzyme that catalyzes the methylation of CpG dinucleotides.

TLS Online TPP Program

#Id: 10430

#Unit 4. Cell Communication and Cell Signaling

SWI/SNF normally plays a role in repressing the E2F genes, inhibiting progression through the cell cycle.