MDM2 levels in the cytoplasm are controlled by

ATR and p14ARF (p19ARF in the mouse), sequesters it in the nucleolus, where it cannot access p53.

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#Unit 8. Inheritance Biology

G-banding patterns reveal that several human chromosomes differ from those of chimpanzees by only a pericentric inversion.

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#Unit 8. Inheritance Biology

An inversion may break a gene into two parts, with one part moving to a new location and destroying the function of that gene.

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#Unit 8. Inheritance Biology

if their positions are altered by an inversion, their expression may be altered, an outcome referred to as a position effect.

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#Unit 8. Inheritance Biology

An inversion moves a wild-type allele (red eyes) at the white locus in Drosophila to a chromosomal region that contains highly condensed, the wild-type allele is not expressed in some cells, resulting in a eye consisting of red and white spots.

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#Unit 8. Inheritance Biology

Inversion homozygous- No special problems arise in meiosis.  Inversion heterozygous- Two chromosomes form an inversion loop

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#Unit 8. Inheritance Biology

Heterozygous for inversions also exhibit reduced recombination among genes located in the inverted region.