Human Bcl-2 and worm CED-9 both proteins contain a single TM domain and are localized to the outer mitochondrial membrane

TLS Online TPP Program

#Id: 8512

#Unit 1. Molecules and their Interaction Relevant to Biology

Prediction of the structure of a protein based only on its chemical and physical properties is done by ab initio (from the beginning) methods is the Rosetta program

TLS Online TPP Program

#Id: 4333

#Unit 1. Molecules and their Interaction Relevant to Biology

About 75% of the charged residues in proteins are members of ion pairs that are located mostly on the protein surface.

Despite the strong electrostatic attraction interactions contribute little to the stability of a native protein.

TLS Online TPP Program

#Id: 4356

#Unit 1. Molecules and their Interaction Relevant to Biology

The overall probability of RNase A re-forming its four native disulfide links at random is-

TLS Online TPP Program

#Id: 4385

#Unit 1. Molecules and their Interaction Relevant to Biology

Proteins fold to their native conformations via directed pathways rather than stumbling on them through random conformational searches.

TLS Online TPP Program

#Id: 8749

#Unit 1. Molecules and their Interaction Relevant to Biology

Intrinsically disordered proteins lack a hydrophobic core, and have high densities of charged amino acid residues such as Lys, Arg, and Glu. Pro residues are also prominent, as they tend to disrupt ordered structures.

TLS Online TPP Program

#Id: 8750

#Unit 1. Molecules and their Interaction Relevant to Biology

The lack of an ordered structure can facilitate a kind of functional promiscuity, allowing one protein to interact with multiple partners. Some intrinsically disordered proteins act to inhibit the action of other proteins by an unusual mechanism: wrapping around their protein targets.