The two cores have different abilities to dissociate from DNA. This corresponds to the need to synthesize 

a continuous leading strand (where polymerase remains associated  with the template) and 

a discontinuous lagging strand (where polymerase repetitively dissociates and reassociates)

TLS Online TPP Program

#Id: 1899

#Unit 4. Cell Communication and Cell Signaling

Negative costimulation

TLS Online TPP Program

#Id: 8447

#Unit 1. Molecules and their Interaction Relevant to Biology

This results in a strong hydrogen bond that has the nearly optimum N…O distance of 2.8 A.

TLS Online TPP Program

#Id: 1843

#Unit 3. Fundamental Processes

The α-amanitin binding site is beneath a “bridge helix” extending across the cleft between the two largest pol II subunits, Rpb1 and Rpb2

TLS Online TPP Program

#Id: 2819

#Unit 13. Methods in Biology

Ion-exchange chromatography relies on the attraction between oppositely charged stationary phase, known as an ion exchanger, and analyte.

TLS Online TPP Program

#Id: 6392

#Unit 2. Cellular Organization

Stimulation of b-galactosidase synthesis by cAMP with wild-type and mutant CAP.