Nurturing Life Sciences
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#Unit 5. Developmental Biology
Sonic hedgehog, is the major active factor in the ZPA.
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The apical ectodermal ridge is a thickening of the ectoderm at the apex of the developing limb bud.
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Fgf8 is the major active factor in the AER.
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Hox11 paralogues specify the zeugopod
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Hox12 and Hox13 paralogues specify the autopod.