Nurturing Life Sciences
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#Unit 5. Developmental Biology
Sigma neoblasts generate a huge variety of cell types, as well as the progenitor population for zeta neoblasts.
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Zeta neoblasts give rise to epidermal cell fates through a prog-1-positive postmitotic precursor state.
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Loss of the zeta population
Epidermal cell types do not fully regenerate in the absence of zeta neoblasts, the remaining neoblasts (likely sigma) and their derived cell types are unaffected.
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In regenerating planaria, Wnt/β-catenin functions to establish anterior-posterior polarity.
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In planaria, Wnts functioning through β-catenin promotes tail development while repressing head regeneration
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In regenerating planaria, β-catenin is activated in the posterior-facing blastema, which generates a tail.
