Cells of the responding tissue must have both, 

A receptor protein for the inducing factor 

The ability to respond to the signal

TLS Online TPP Program

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#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene

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#Id: 10452

#Unit 4. Cell Communication and Cell Signaling

Philadelphia chromosome generated by a translocation

between chromosomes 22 and 9

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#Id: 10453

#Unit 4. Cell Communication and Cell Signaling

Translocation between chromosomes 22 and 9 form new oncogenic fusion protein - BCR-ABL hybrid protein kinase

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#Unit 4. Cell Communication and Cell Signaling

BCR-ABL fusion protein is a constitutively active

kinase that phosphorylates multiple signal-transducing proteins. 

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#Unit 4. Cell Communication and Cell Signaling

Chronic myelogenous leukemia, 

a common leukemia in humans, associated with the Philadelphia chromosome

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#Id: 10456

#Unit 4. Cell Communication and Cell Signaling

A highly specific inhibitor imatinib (Gleevec), which

binds directly to the active site of the ABL kinase and holds it in an inactive conformation to inhibit its kinase activity, is lethal to CML cells