TLS Online TPP Program

#Id: 5186

#Unit 7. System Physiology – Animal

The fundamental reaction is conversion of the soluble plasma protein fibrinogen to insoluble fibrin.

TLS Online TPP Program

#Id: 5187

#Unit 7. System Physiology – Animal

The fibrin is initially a loose mesh of interlacing strands. It is converted by the formation of covalent cross linkages to a dense, tight aggregate (stabilization). 

TLS Online TPP Program

#Id: 5188

#Unit 7. System Physiology – Animal

The initial reaction in the intrinsic system is conversion of inactive factor XII to active factor XII (XIIa).

TLS Online TPP Program

#Id: 5189

#Unit 7. System Physiology – Animal

kininogen and kallikrein, can be brought about 

In vitro by exposing the blood to glass

In vivo by collagen fibers underlying the endothelium

TLS Online TPP Program

#Id: 5190

#Unit 7. System Physiology – Animal

Active factor XII then activates  factor XI, & active factor XI activates factor IX.

TLS Online TPP Program

#Id: 5191

#Unit 7. System Physiology – Animal

Activated factor IX forms a complex with active factor VIII, which is activated when it is separated from von Willebrand factor.