Lioyd and Hunt, applies only to sensory nerve fibers and uses a Roman numeral nomenclature of I, II, III, and IV

TLS Online TPP Program

#Id: 1428

#Unit 4. Cell Communication and Cell Signaling

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.

TLS Online TPP Program

#Id: 1429

#Unit 4. Cell Communication and Cell Signaling

Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.

TLS Online TPP Program

#Id: 1430

#Unit 4. Cell Communication and Cell Signaling

Integrins are involved in biological activities, includes: 

Extravasation

Cell-to-cell adhesion

Cell migration

Receptors for certain viruses

Angiogenesis

Apoptosis

TLS Online TPP Program

#Id: 1431

#Unit 4. Cell Communication and Cell Signaling

Integrins can mediate outside-in and inside-out signaling

TLS Online TPP Program

#Id: 1432

#Unit 4. Cell Communication and Cell Signaling

Hemidesmosomes are integrin-containing anchoring junctions that attach cells to elements of the underlying extracellular matrix.

TLS Online TPP Program

#Id: 1433

#Unit 4. Cell Communication and Cell Signaling

Integrins have an important function in neuroregeneration after injury of the peripheral nervous system.