Nurturing Life Sciences
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#Unit 6. System Physiology – Plant
transfer of four protons from the matrix to the intermembrane space is an endergonic process
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Complex I is therefore a proton pump
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Pumping of proton is driven by the the energy transfer of electron, and the reaction it catalyzes is vectorial
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vertical movement of proton from IMS to matrix is an energy driven process which is compensate by movement of electron within the membrane
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Amytal (a barbiturate drug), rotenone (a plant product commonly used as an insecticide), and piericidin A (an antibiotic) inhibit electron flow from the Fe-S centers of Complex I to ubiquinone
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Protein components of the mitochondrial electron-transfer chain