Schwann cells are involved in myelin formation around axons in the peripheral nervous system.

TLS Online TPP Program

#Id: 1929

#Unit 4. Cell Communication and Cell Signaling

Alternative Properdin-Activated Pathway

TLS Online TPP Program

#Id: 1930

#Unit 4. Cell Communication and Cell Signaling

The Alternative Protease-Activated Pathway

Thrombin, could cleave the complement components C3 and C5.

TLS Online TPP Program

#Id: 1931

#Unit 4. Cell Communication and Cell Signaling

When blood platelets are activated during a clotting reaction, they release high concentrations of ATP and Ca2+ along with serine/threonine kinases. Phosphorylated C3b is less susceptible to proteolytic degradation than its unphosphorylated form

TLS Online TPP Program

#Id: 1932

#Unit 4. Cell Communication and Cell Signaling

The Three Complement Pathways Converge at the Formation of the C5 Convertase. 

TLS Online TPP Program

#Id: 1933

#Unit 4. Cell Communication and Cell Signaling

C5 Initiates the Generation of the MAC

TLS Online TPP Program

#Id: 1934

#Unit 4. Cell Communication and Cell Signaling

C8 is made up of two peptide chains: C8β and C8αϒ. 

Binding of C8β to the C5b67 complex induces a conformational change in the C8 dimer such that the hydrophobic domain of C8αϒ can insert into the interior of the phospholipid membrane.