Nurturing Life Sciences
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#Unit 3. Fundamental Processes
Pol h (but not other translesion polymerases) correctly inserts As across from a thymine dimer, the use of other translesion polymerases may increase the frequency of mutagenesis
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Direct repair of alkylated bases by AlkB
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Methyltransferase catalyzes the transfer of the methyl group on O6 -methylguanine to a cysteine residue on the enzyme, thereby restoring the normal G in DNA.
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Photoreactivation directly reverses the formation of pyrimidine dimers that result from ultraviolet irradiation.
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In photoreactivation, the enzyme DNA photolyase captures energy from light and uses it to break the covalent bonds linking adjacent pyrimidines.