ACTH stimulates the synthesis and secretion of cortisol by the activation of adenylyl cyclase via Gs.

TLS Online TPP Program

#Id: 446

#Unit 2. Cellular Organization

Linker DNA comprises the rest of the repeating unit. Its length varies from as little as 8 bp to as many as 114 bp per nucleosome.

TLS Online TPP Program

#Id: 447

#Unit 2. Cellular Organization

The predicted mass of the nucleosome is 262 kD.

TLS Online TPP Program

#Id: 448

#Unit 2. Cellular Organization

The nucleosome consists of approximately equal masses of DNA and histones (including H1).

TLS Online TPP Program

#Id: 449

#Unit 2. Cellular Organization

H32-H42 tetramer accounts for the diameter of the octamer. It forms the shape of a horseshoe.

TLS Online TPP Program

#Id: 450

#Unit 2. Cellular Organization

All four core histones show a similar type of structure in which three a-helices are connected by two loops. This highly conserved structure is called the histone fold.

TLS Online TPP Program

#Id: 451

#Unit 2. Cellular Organization

Nucleosomes that contain linker H1 histones are referred to as chromatosomes.