E1’s ion-binding sites are exposed to the cytoplasm, and it has high affinity for Na+ but low affinity for K+

TLS Online TPP Program

#Id: 8383

#Unit 2. Cellular Organization

All Myosins move toward the (+) end of an actin filament except myosin VI. Myosin VI move toward the (−) end of an actin filament

TLS Online TPP Program

#Id: 8384

#Unit 2. Cellular Organization

The length of the myosin II neck domain determines the rate of movement.

TLS Online TPP Program

#Id: 8385

#Unit 2. Cellular Organization

In the absence of ATP, the myosin head is firmly attached to the actin filament. 

TLS Online TPP Program

#Id: 8386

#Unit 2. Cellular Organization

In the presence of ATP,  myosin head releases from the actin filament. 

TLS Online TPP Program

#Id: 8387

#Unit 2. Cellular Organization

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8388

#Unit 2. Cellular Organization

Smooth muscle cells and nonmuscle cells are regulated by:

Norepinephrine, angiotensin, endothelin, histamine