Phosphorylation of MLC  unfolds the myosin II, active and can assemble into bipolar filaments for contraction. 

TLS Online TPP Program

#Id: 8412

#Unit 2. Cellular Organization

Binding of Ca2+ ions to TN-C

triggers movement of TM to a new position on the filament, thereby exposing the myosin-binding sites on actin.

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#Id: 8413

#Unit 2. Cellular Organization

Troponin C is closely related to the ubiquitous 

Ca2+-binding protein calmodulin

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#Id: 8414

#Unit 2. Cellular Organization

Familial hypertrophic cardiomyopathy

point mutations in cardiac β-myosin heavy chain gene mutations in other genes encoding contractile proteins including myosin light chains, cardiac troponin,

and tropomyosin. 

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#Id: 8415

#Unit 2. Cellular Organization

Dilated cardiomyopathy

Minor missense mutations in the cardiac actin gene

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#Id: 8513

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8514

#Unit 2. Cellular Organization