The M C M 2 - 7 proteins form a six-member ring-shaped complex around DNA. MCM 2, 3, 5 are regulatory, while MCM4,6,7 have helicase activity.

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#Unit 3. Fundamental Processes

Before replication, the palindromic target site is methylated on the adenines of each strand.

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#Unit 3. Fundamental Processes

Replication inserts the normal (nonmodified) bases into the daughter strands. This generates hemimethylated DNA, in which one strand is methylated and one strand is unmethylated.

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#Unit 3. Fundamental Processes

Initiation may require full methylation of the Dam target sites in the origin, or it may be inhibited by hemimethylation of these sites.

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#Unit 3. Fundamental Processes

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#Unit 3. Fundamental Processes

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#Unit 3. Fundamental Processes