TLS Online TPP Program

#Id: 7255

#Unit 5. Developmental Biology

B cells can be negatively signaled through CD22 and FcγRIIb a receptor that recognizes the presence of IgG containing immune complexes in the blood.

TLS Online TPP Program

#Id: 7256

#Unit 5. Developmental Biology

B-10 B cells release the interleukin IL-10 upon antigenic stimulation, and may serve to reduce inflammation during an ongoing immune response.

TLS Online TPP Program

#Id: 7361

#Unit 5. Developmental Biology

On the left side of Hensen’s node, Sonic hedgehog (Shh) activates Cerberus, which stimulates BMPs to induce the expression of Nodal

TLS Online TPP Program

#Id: 7362

#Unit 5. Developmental Biology

In the presence of Nodal, the Pitx2 gene is activated

TLS Online TPP Program

#Id: 7363

#Unit 5. Developmental Biology

On the right side of the embryo, activin is expressed, along with activin receptor IIa. This activates Fgf8, a protein that blocks expression of the gene for Cerberus.

TLS Online TPP Program

#Id: 7364

#Unit 5. Developmental Biology

In the absence of Cerberus, Nodal is not activated and thus Pitx2 is not expressed