Nurturing Life Sciences
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#Unit 4. Cell Communication and Cell Signaling
Phosphorylation of two serines in Ser-X-Ser motif at the extreme C-terminus of the MH2 domain by the activated RI separates the two domains, exposing the NLS for binding to importins
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Simultaneously, two serines in each Smad2/3 phosphorylated by RI receptor kinase bind to phosphoserine-binding sites in the MH2 domains of a Smad4
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