Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by loss of both alleles of NF1, which encodes a RAS GAP-type protein.

TLS Online TPP Program

#Id: 9878

#Unit 4. Cell Communication and Cell Signaling

Antimicrobial proteins

TLS Online TPP Program

#Id: 9879

#Unit 4. Cell Communication and Cell Signaling

Antimicrobial peptide

TLS Online TPP Program

#Id: 9880

#Unit 4. Cell Communication and Cell Signaling

Antimicrobial peptides generally are cysteine-rich, cationic, and amphipathic. 

Because of their positive charge and amphipathic nature, they interact with acidic phospholipids in lipid bilayers, forming pores and disrupting the membranes of bacteria, fungi, parasites, and viruses.

TLS Online TPP Program

#Id: 9881

#Unit 4. Cell Communication and Cell Signaling

Defensins and cathelicidin LL-37 are secreted constitutively by epithelial cells in many tissues, and are stored as well in neutrophil granules, where they contribute to killing phagocytosed microbes.

TLS Online TPP Program

#Id: 9882

#Unit 4. Cell Communication and Cell Signaling

Cellular innate immune responses

TLS Online TPP Program

#Id: 9883

#Unit 4. Cell Communication and Cell Signaling

Phagocytosis