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TLS Online TPP Program

#Id: 2394

In C. elegans, about 70% of genes are processed by the trans-splicing mechanism

#Unit 3. Fundamental Processes #Splicing #Part B Pointers
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TLS Online TPP Program

#Id: 8347

#Unit 2. Cellular Organization

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)
TLS Online TPP Program

#Id: 8348

#Unit 2. Cellular Organization

The major NPF family is characterized by the presence of a region called WCA (WH2, connector, acidic)
TLS Online TPP Program

#Id: 8349

#Unit 2. Cellular Organization
TLS Online TPP Program

#Id: 8350

#Unit 2. Cellular Organization

One NPF is called WASp, as it is defective in patients with Wiskott-Aldrich syndrome.
TLS Online TPP Program

#Id: 8351

#Unit 2. Cellular Organization

WASp activation requires two signals (This type of two-signal input, called coincidence detection):
1. regulatory phospholipid PIP2
2. small GTP-binding protein Cdc42
TLS Online TPP Program

#Id: 8353

#Unit 2. Cellular Organization

A second NPF is a large protein complex called WAVE
and requires small GTP-binding protein Rac1.