Ski recruits N-CoR, which binds directly to mSin3A; mSin3A interacts with HDAC, that promotes histone deacetylation on nearby promoters, repressing gene expression

TLS Online TPP Program

#Id: 10542

#Unit 4. Cell Communication and Cell Signaling

DNA damage or UV irradiation leads to induction of synthesis of the BH3-only Puma protein which binds to Bak and Bax as well as to Bcl-2, allowing Bak and

Bax to form oligomeric pores.

TLS Online TPP Program

#Id: 10543

#Unit 4. Cell Communication and Cell Signaling

Removal of a cell from its substratum disrupts integrin signaling, leading to release of the BH3-only Bim

protein from the cytoskeleton which binds to Bak and Bax to promote pore formation.

TLS Online TPP Program

#Id: 10544

#Unit 4. Cell Communication and Cell Signaling

Two BH3-only proteins, Puma and Noxa are transcriptionally induced by the p53 protein

TLS Online TPP Program

#Id: 10545

#Unit 4. Cell Communication and Cell Signaling

Binding of cytochrome c to the Apaf1 triggers formation of an apoptosome containing seven molecules each of Apaf and cytochrome c and having a sevenfold symmetry. 

TLS Online TPP Program

#Id: 10546

#Unit 4. Cell Communication and Cell Signaling

Apoptosome 

a disk-shaped 1.4-MDa heptameric wheel of death

TLS Online TPP Program

#Id: 10547

#Unit 4. Cell Communication and Cell Signaling

Apoptosis of mammalian cells is activated by either: Intrinsic signaling pathways

Extrinsic signaling pathways