The chromodomain is a common protein motif of 60 amino acid that recognizes methylated lysine and Arg. 

TLS Online TPP Program

#Id: 4762

#Unit 5. Developmental Biology

In mex-3-deficient mutants, PAL-1 is seen in every blastomere.

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#Id: 4763

#Unit 5. Developmental Biology

SKN-1 also inhibits PAL-1 (preventing it from becoming active in the EMS cell).

TLS Online TPP Program

#Id: 4764

#Unit 5. Developmental Biology

In the germ line, PAL-1 synthesis is prevented by the PUF-8 protein, which binds to the 3′ UTR of pal-1 mRNA and blocks its translation.

TLS Online TPP Program

#Id: 4765

#Unit 5. Developmental Biology

 PIE -1, is necessary for germline cell fate.

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#Id: 4766

#Unit 5. Developmental Biology

PIE-1 is placed into the P blastomeres through the action of the PAR-1 protein & it inhibit both SKN-1 and PAL-1 function in the P2 and subsequent germline cells.

TLS Online TPP Program

#Id: 4767

#Unit 5. Developmental Biology

Mutations of the maternal pie-1 gene result in germline blastomeres adopting somatic fates, with the P2 cell behaving similarly to a wild-type EMS blastomere.