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TLS Online TPP Program

#Id: 1523

Primary building block of intermediate filaments is a dimer held together through the rod domains, which associate as a coiled coil.

#Unit 2. Cellular Organization #Intermediate Filaments #Part B Pointers
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TLS Online TPP Program

#Id: 1690

#Unit 4. Cell Communication and Cell Signaling

Site of DNA cleavage- Recombination Signal Sequence (RSS) 
TLS Online TPP Program

#Id: 1691

#Unit 4. Cell Communication and Cell Signaling
TLS Online TPP Program

#Id: 1692

#Unit 4. Cell Communication and Cell Signaling

Recognition of Recombination Signal Sequence (RSS) by the RAG1/RAG2 enzyme complex.
TLS Online TPP Program

#Id: 1693

#Unit 4. Cell Communication and Cell Signaling

RAG1 is expressed at all phases of the cell cycle, RAG2 is stable only in G0- or G1-phase cells.
TLS Online TPP Program

#Id: 1694

#Unit 4. Cell Communication and Cell Signaling

Threonine residue T490 on RAG2 is phosphorylated during the S, G2, and M phases of the cell cycle, and this phosphorylation triggers the destruction of RAG2.
TLS Online TPP Program

#Id: 1695

#Unit 4. Cell Communication and Cell Signaling

RAG1 is the predominant recombinase; it forms a complex with the RSS that is stabilized by the binding of RAG2.
RAG2 by itself does not exhibit detectable RSS binding activity