FcεRI signalling through Lyn and Syk kinases also activates E3 ubiquitin ligases, including c-Cbl. Cbl ubiquitinylates Lyn and Syk, as well as FcεRI itself, triggering their degradation.
#Unit 4. Cell Communication and Cell Signaling#Hypersensitivity and autoimmunity#Part B Pointers