Development of T cells from hematopoietic stem cells on bone marrow stromal cells expressing the Notch ligand.

TLS Online TPP Program

#Id: 10014

#Unit 4. Cell Communication and Cell Signaling

Transcription Factor

zinc-finger transcription factor Cubitis interruptus

TLS Online TPP Program

#Id: 10015

#Unit 4. Cell Communication and Cell Signaling

A cytosolic complex contains

kinases Fused ; PKA, GSK3β, and CK1, Ci, and SUFU

TLS Online TPP Program

#Id: 10016

#Unit 4. Cell Communication and Cell Signaling

Cytosolic complex is bound to a microtubule by the kinesin-related motor protein Costal-2 (Cos2).

TLS Online TPP Program

#Id: 10017

#Unit 4. Cell Communication and Cell Signaling

In this complex, Ci becomes phosphorylated in a series of steps catalyzed by PKA, GSK3β, and CK1.

TLS Online TPP Program

#Id: 10018

#Unit 4. Cell Communication and Cell Signaling

The phosphorylated Ci is proteolytically cleaved by the ubiquitin-proteasome pathway, generating an N-terminal fragment Ci75, which functions as a transcriptional repressor of Hh target genes.

TLS Online TPP Program

#Id: 10019

#Unit 4. Cell Communication and Cell Signaling

Hh binds to Ptc, causing Ptc to be endocytosed from the cell surface and degraded, relieving the inhibition of Smo.