The principal cells are the primary sites of action of the potassium-sparing diuretics, including spironolactone, eplerenone, amiloride, and triamterene

TLS Online TPP Program

#Id: 7877

#Unit 2. Cellular Organization

The cristae’s membranes are the site of ATP synthesis thus the invaginations increase the mitochondrion’s capacity to generate ATP.

TLS Online TPP Program

#Id: 7878

#Unit 2. Cellular Organization

Crista junction

The connection between the inner boundary membrane and a crista

TLS Online TPP Program

#Id: 7879

#Unit 2. Cellular Organization

The curvature of the crista junctions is due to a protein complex called MICOS (mitochondrial contact site and cristae organizing system).

TLS Online TPP Program

#Id: 7880

#Unit 2. Cellular Organization

MICOS has an integral membrane protein subunit that homo-oligomerizes and bends the inner membrane to produce high curvature.

TLS Online TPP Program

#Id: 7881

#Unit 2. Cellular Organization

MICOS mediates close juxtaposition of the outer membrane and inner membrane by binding to outer membrane–associated proteins

TLS Online TPP Program

#Id: 7882

#Unit 2. Cellular Organization

The binding partners for MICOS in the outer membrane are Tom and SAM protein complexes, (involved in import of proteins into the mitochondria).