TLS Online TPP Program

#Id: 2080

#Unit 8. Inheritance Biology

Edwards syndrome (trisomy 18) occurs when a person has an extra copy of chromosome 18.

TLS Online TPP Program

#Id: 2081

#Unit 8. Inheritance Biology

Burkitt lymphoma possess a reciprocal translocation of c-MYC  gene between chromosome 8 and chromosome 2, 14, or 22

TLS Online TPP Program

#Id: 2082

#Unit 8. Inheritance Biology

A reciprocal translocation between the long arm of chromosome 22 and the tip of the long arm of chromosome 9 . This translocation produces a shortened chromosome 22, called the Philadelphia chromosome

TLS Online TPP Program

#Id: 6421

#Unit 8. Inheritance Biology

Pedigree

Pictorial representation of a family history outlining the inheritance of one or more traits or diseases.

TLS Online TPP Program

#Id: 6422

#Unit 8. Inheritance Biology

Autosomal Recessive Traits

Autosomal recessive traits normally appear with equal frequency in both sexes.

The trait seems to skip generations.

When both parents are heterozygous, approximately one-fourth of the offspring are expected to express the trait.

Recessive traits appear more frequently among the offspring of consanguineous matings.

Example - Tay–Sachs disease, sickle cell anemia, cystic fibrosis, PKU

TLS Online TPP Program

#Id: 6423

#Unit 8. Inheritance Biology

Autosomal dominant 

Traits appear in both sexes with equal frequency.

Both sexes are capable of transmitting these traits to their offspring.

An affected person has an affected parent (unless the person carries new mutations). 

The trait does not skip generations.

Unaffected people do not transmit the trait. 

Example- familial hypercholesterolemia, Huntington disease, Neurofibromatosis