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#Unit 3. Fundamental Processes
Mutations in MutS/L components can lead to hereditary nonpolyposis colorectal cancer (HNPCC). A characteristic feature of HNPCC is microsatellite instability, in which the lengths (numbers of repeats) of microsatellite sequences change rapidly in the tumor cells due to the loss of the mismatch repair system to correct replication slippage in these sequences.