Polygenic Inheritance- Multiple gene one function

TLS Online TPP Program

#Id: 385

#Unit 2. Cellular Organization

H32-H42 tetramer accounts for the diameter of the octamer and H32-H42 tetramer alone can organize DNA in vitro into particles that display the properties of the core particle.

 

TLS Online TPP Program

#Id: 386

#Unit 2. Cellular Organization

The H32.H42 tetramer bound to DNA recruits two copies of the H2A.H2B dimer to complete the assembly of the final nucleosome

TLS Online TPP Program

#Id: 387

#Unit 2. Cellular Organization

The nucleosome has an approximate twofold axis of symmetry, called the dyad axis.

TLS Online TPP Program

#Id: 388

#Unit 2. Cellular Organization

DNA enters at 1 o’clock and exits at just short of 11 o’clock on one axis and they change time after 180 degree rotation

TLS Online TPP Program

#Id: 389

#Unit 2. Cellular Organization

The H3.H4 tetramers and H2A.H2B dimers each interact with a particular region of the DNA within the nucleosome can be shown by clock analogy.

 

TLS Online TPP Program

#Id: 390

#Unit 2. Cellular Organization

Of the 147 bp of DNA included in the structure, the histone-fold regions of the H3.H4 tetramer interact with the central 60 bp.