Phylogenetic relationships are based on,

a. Plesiomorphic character

b. Apomorphic character

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#Unit 4. Cell Communication and Cell Signaling

Burkitt’s lymphoma

translocation between chromosomes 8 and 14

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#Id: 10461

#Unit 4. Cell Communication and Cell Signaling

In Burkitt’s lymphoma cells, 

MYC is translocated close to an antibody gene, leading to overproduction of MYC

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#Unit 4. Cell Communication and Cell Signaling

MYC gene encodes a basic helix-loop-helix protein

include MAD, MAX, and MNT

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#Unit 4. Cell Communication and Cell Signaling

MYC-MAX dimers regulate genes that control proliferation, such as cyclins.

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#Id: 10464

#Unit 4. Cell Communication and Cell Signaling

MAD and MNT work with the SIN3 co-repressor protein to bring in histone deacetylases that help to block transcription

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#Id: 10465

#Unit 4. Cell Communication and Cell Signaling

A classic inherited cancer syndrome is retinoblastoma, which is caused by loss of function of RB.