Splice sites are directional in nature. 5’ splice site -the left, or donor, site and the 3’ splice site - right, or acceptor, site.

TLS Online TPP Program

#Id: 10450

#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity is constitutive

TLS Online TPP Program

#Id: 10451

#Unit 4. Cell Communication and Cell Signaling

Chromosomal translocation 

That brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene

TLS Online TPP Program

#Id: 10452

#Unit 4. Cell Communication and Cell Signaling

Philadelphia chromosome generated by a translocation

between chromosomes 22 and 9

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#Id: 10453

#Unit 4. Cell Communication and Cell Signaling

Translocation between chromosomes 22 and 9 form new oncogenic fusion protein - BCR-ABL hybrid protein kinase

TLS Online TPP Program

#Id: 10454

#Unit 4. Cell Communication and Cell Signaling

BCR-ABL fusion protein is a constitutively active

kinase that phosphorylates multiple signal-transducing proteins. 

TLS Online TPP Program

#Id: 10455

#Unit 4. Cell Communication and Cell Signaling

Chronic myelogenous leukemia, 

a common leukemia in humans, associated with the Philadelphia chromosome